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Tiplaxtinin 393105-53-8

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Synonyms ：
Appearance ：
Chemical Formula ：
C24H16F3NO4
Solubility ：
Molecular Weight ：
439.38
Storage and Stability ：
in stock
CAS No. ：
393105-53-8
Purity ：
98%+
Introduction
In a panel of human bladder cell lines, PAI-1 results in the reduction of cellular proliferation, cell adhesion, and colony formation, and the induction of apoptosis and anoikis

In a rat carotid thrombosis model, Tiplaxtinin (1 mg/kg, p.o.) increases time to occlusion and prevents the carotid blood flow reduction. In C57BL/6J mice, (1 mg/g chow) attenuates Ang II-induced aortic remodeling.  In untreated type 1 diabetic mice, Tiplaxtinin (p.o.) restores skeletal muscle regeneration. In athymic mice bearing human cancer cell line T24 and HeLa xenografts, Tiplaxtinin (1 mg/kg, p.o.) reduces tumor xenograft growth, associated with a reduction in tumor angiogenesis, a reduction in cellular proliferation, and an increase in apoptosis.

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