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Bardoxolone Methyl 218600-53-4

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Synonyms ：
Appearance ：
Chemical Formula ：
C32H43NO4
Solubility ：
Molecular Weight ：
505.69
Storage and Stability ：
in stock
CAS No. ：
218600-53-4
Purity ：
98%+
Introduction
Bardoxolone Methyl exhibits potent inhibitory activities against production of nitric oxide induced by interferon-Ƴ in mouse macrophages with IC50 of 0.1 nM.  Bardoxolone Methyl decreases the viability of leukemic HL-60, KG-1, and NB4 cells with IC50 of 0.4, 0.4, and 0.27 μM, respectively. CDDO-Me induces pro-apoptotic Bax protein, inhibits the activation of ERK1/2, and it blocks Bcl-2 phosphorylation, which contributes to the induction of apoptosis. Bardoxolone Methyl potently inhibits both constitutive and inducible NF-kappaB activated by TNF, interleukin (IL)-1beta, phorbol ester, okadaic acid, hydrogen peroxide, lipopolysaccharide, and cigarette smoke

Bardoxolone Methyl (60 mg/kg) reduces the number, size, and severity of lung tumors in vivo.  Bardoxolone Methyl significantly reduces the in vivo inflammatory cytokine response following LPS challenge, induces HO-1 protein expression in the spleen, and protects mice against lethal-dose LPS

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