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GSK1324726A 1300031-52-0

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Synonyms ：
Appearance ：
Chemical Formula ：
C25H23ClN2O3
Solubility ：
Molecular Weight ：
434.91
Storage and Stability ：
in stock
CAS No. ：
1300031-52-0
Purity ：
98%+
Introduction
In neuroblastoma cell lines, GSK1324726A inhibits cell growth and induces cytotoxicity. GSK1324726A also modulates expression of genes involved in apoptosis, signaling, and MYC-family pathways, including the direct suppression of BCL2 and MYCN.

In the mouse SK–N-AS and CHP-212 models, GSK1324726A (15 mg/kg p.o.) results in tumor growth inhibition and down-regulation MYCN and BCL2 expression. In a mouse septic shock model, GSK1324726A (10 mg/kg i.v.) shows potent anti-inflammatory effects, and prevents death of diseased animals. 


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