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PF-06447475 1527473-33-1

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Synonyms ：
Appearance ：
Chemical Formula ：
C17H15N5O
Solubility ：
Molecular Weight ：
305.33
Storage and Stability ：
in stock
CAS No. ：
1527473-33-1
Purity ：
98%+
Introduction
In the macrophage cell line Raw264.7, PF-06447475 inhibits endogenous LRRK2 kinase activity with IC50 of <10 nM. In astrocytes, PF-06447475 rescues LRRK2 mutation-induced defects in lysosomal morphology and function.

In G2019S BAC-transgenic mice, PF-06447475 (100 mg/kg, p.o.) inhibits pS935 and pS1292 phosphorylation of LRRK2 with IC50 of 103 nM and 21 nM, respectively. In G2019S-LRRK2 rats, PF-06447475 (30 mg/kg, p.o.) blocks α-synuclein-induced dopaminergic neurodegeneration and attenuates neuroinflammation associated with G2019S-LRRK2 expression.

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