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SP2509 1423715-09-6

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Synonyms ：
Appearance ：
Chemical Formula ：
C19H20ClN3O5S
Solubility ：
Molecular Weight ：
437.90
Storage and Stability ：
in stock
CAS No. ：
1423715-09-6
Purity ：
98%+
Introduction
In AML cells, SP2509 inhibits the association of LSD1 with CoREST, increases promoter-specific H3K4Me3 and induces p53, p21 and C/EBPα. SP2509 also significantly inhibits the colony growth and induces apoptosis of OCI-AML3. In addition, SP2509 induces differentiation of cultured and primary AML cells, and exerts synergistic lethal activity when used in combination with panobinostat. 

In mice bearing OCI-AML3 xenografts, SP2509 (25 mg/kg i.p.) significantly improved the survival of the mice, while co-treatment with SP2509 and panobinostat exerts superior in vivo activity

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