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ISRIB 1597403-47-8

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Synonyms ：
Appearance ：
Chemical Formula ：
C22H24Cl2N2O4
Solubility ：
Molecular Weight ：
451.34
Storage and Stability ：
in stock
CAS No. ：
1597403-47-8
Purity ：
98%+
Introduction
ISRIB blocks production of endogenous ATF4, whereas XBP1 mRNA splicing and XBP1s production persisted. ISRIB prevents cells from re-establishing ER homeostasis by blocking signaling through the PERK branch of the UPR, and decreases the viability of cells that are subjected to ER-stress.

ISRIB shows favorable properties in pharmacokinetic profiling experiments and good bioavailability in vivo. ISRIB (0.25 mg/kg i.p.) increases long-term memory in mice by enhancing spatial and fear-associated learning.

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