Pifithrin-α 63208-82-2

1.Inquiries will be replied within 24 hours

2.We could supply various packages as you required

3.To protect the profit of our agents, price will not show on website, please send inquiries to get the price.

4.Fast delivery, goods arrive your office within 3 to 5 days

5.Please click "Inquiry" or "Email" below to get the price

Synonyms

：

Appearance

：

Chemical Formula

：

C16H18N2OS.HBr

Solubility

：

Molecular Weight

：

367.3

Storage and Stability

：

in stock

CAS No.

：

63208-82-2

Purity

：

98%+

Introduction

Pifithrin-α inhibits p53-dependent transactivation of p53-responsive genes in ConA cells. Pifithrin-α (10 μM) inhibits apoptotic death of C8 cells induced by Dox, etoposide, Taxol, cytosine arabinoside. Pifithrin-α inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Pifithrin-α may modulate the nuclear import or export (or both) of p53 or may decrease the stability of nuclear p53. Pifithrin-α (100-200 nM) completely suppresses the camptothecin-induced increase in the level of p53 DNA binding as well as the p53-responsive gene Bax in hippocampal cell. Pifithrin-α also decreases the basal level of p53 DNA-binding activity. Pifithrin-α (200 nM) protects cultured hippocampal neurons against death induced by DNA-damaging agents. Pifithrin-α (200 μM) stabilizes mitochondrial function, suppresses caspase activation and protects cultured hippocampal neurons against death induced by glutamate and amyloid β-peptide. Pifithrin α, in addition to p53, can suppress heat shock and glucocorticoid receptor signaling but has no effect on nuclear factor-kappaB signaling. Pifithrin α (10 μM) reduces activation of heat shock transcription factor (HSF1) and increases cell sensitivity to heat. Pifithrin α (10 μM) reduces activation of glucocorticoid receptor and rescues mouse thymocytes from apoptotic death after dexamethasone treatment in HeLa cells. PFTalpha blocks p53-mediated induction of p21/Waf-1 in human embryonic kidney cells. PFTalpha does, however, cause a left shift in the dexamethasone dose response curve by increasing intracellular dexamethasone concentration.

Products for scientific research use only

Pifithrin-α 63208-82-2

Thank you for your company product support!

CAS No. ：

Product Name ：

Number ：

Your name：
*

Phone：

Email：
*

The company or laboratory name：
*

Pifithrin-α 63208-82-2

Thank you for your company product support!

CAS No. ：

Product Name ：

Number ：

Your name： *

Phone：

Email： *

The company or laboratory name： *

Your name：
*

Email：
*

The company or laboratory name：
*