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SH-4-54 1456632-40-8

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Synonyms ：
Appearance ：
Chemical Formula ：
C29H27F5N2O5S
Solubility ：
Molecular Weight ：
610.59
Storage and Stability ：
in stock
CAS No. ：
1456632-40-8
Purity ：
98%+
Introduction
SH-4-54 shows unprecedented cytotoxicity in human glioblastoma brain cancer stem cells (BTSCs), while has no toxicity in human fetal astrocytes. In addition, SH-4-54 effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets. 

In mice orthotopically xenografted with BT73, SH-4-54 (10 mg/kg i.p.) exhibits BBB permeability, potently suppresses glioma tumor growth, and inhibits pSTAT3

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