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URMC-099 1229582-33-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C27H27N5
Solubility ：
Molecular Weight ：
421.54
Storage and Stability ：
in stock
CAS No. ：
1229582-33-5
Purity ：
98%+
Introduction
URMC-099 inhibits LPS-induced TNFα release in microglial cells, and HIV-1 Tat-induced release of cytokines in human monocytes.  URMC-099 prevents destruction and phagocytosis of cultured neuronal axons by microglia cells. URMC-099 reduces fMLP-induced chemotaxis of wild-type neutrophil in vitro. 

In mice, URMC-099 shows excellent pharmacokinetic properties and improved CNS penetration.  In vivo, URMC-099 (10 mg/kg i.p.) reduces inflammatory cytokine production, protects neuronal architecture, and alters the morphologic and ultrastructural response of microglia to HIV-1 Tat exposure.  URMC099 significantly reduces recruitment of neutrophils into the peritoneum by fMLP in wild-type mice. 

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