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TAPI-1 171235-71-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C26H37N5O5
Solubility ：
Molecular Weight ：
499.60
Storage and Stability ：
in stock
CAS No. ：
171235-71-5
Purity ：
98%+
Introduction
TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes.  TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695).  TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells. 

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