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BRD73954 1440209-96-0

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Synonyms ：
Appearance ：
Chemical Formula ：
C16H16N2O3
Solubility ：
Molecular Weight ：
284.31
Storage and Stability ：
in stock
CAS No. ：
1440209-96-0
Purity ：
98%+
Introduction
As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation.

BRD73954 is a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.

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