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YK-4-279 1037184-44-3

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Synonyms ：
Appearance ：
Chemical Formula ：
C17H13Cl2NO4
Solubility ：
Molecular Weight ：
366.20
Storage and Stability ：
in stock
CAS No. ：
1037184-44-3
Purity ：
98%+
Introduction
YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. YK-4-279 also specifically inhibits ESFT cell growth and induces apoptosis. YK-4-279 also inhibits ERG and ETV1 biological activity in fusion-positive prostate cancer cells, and further decreases cell motility and invasion. 

In vivo, YK-4-279 (1.5 mg/dose i.p.) inhibits the growth of ESFT xenograft tumors. [1] In mouse model, YK-4-279 selectively prevents prostate cancer growth and metastasis in fusion-positive LNCaP-luc-M6 tumors.

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