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YH239-EE 1364488-67-4

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Synonyms ：
Appearance ：
Chemical Formula ：
C25H27Cl2N3O4
Solubility ：
Molecular Weight ：
504.41
Storage and Stability ：
in stock
CAS No. ：
1364488-67-4
Purity ：
98%+
Introduction
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).

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