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XEN445 1515856-92-4

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Synonyms ：
Appearance ：
Chemical Formula ：
C18H17F3N2O3
Solubility ：
Molecular Weight ：
366.33
Storage and Stability ：
in stock
CAS No. ：
1515856-92-4
Purity ：
98%+
Introduction
XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.

XEN445 shows good in vitro inhibitory potency against EL, and high selectivity over LPL and HL. 

In vivo, XEN445 displays good ADME and PK properties. In mice, XEN445 (30 mg/kg, p.o.) raises plasma HDL-cholesterol concentration. 

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