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VE-821 1232410-49-9

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Synonyms ：
Appearance ：
Chemical Formula ：
C18H16N4O3S
Solubility ：
Molecular Weight ：
368.41
Storage and Stability ：
in stock
CAS No. ：
1232410-49-9
Purity ：
98%+
Introduction
VE-821 shows excellent selectivity for ATR with minimal cross-reactivity against the related PIKKs ATM, DNA-PK, mTOR and PI3K (Kis of 16 μM, 2.2 μM, >1 μM and 3.9 μM, respectively. VE-821 alone commits a large fraction of cancer cell populations to death, but it only reversibly limits cell cycle progression in normal cells, with minimal death or long-term detrimental effects. VE-821 along with cisplatin treatment shows the most marked synergy. VE-821 inhibits H2AX cell growth with IC50 of 800 nM. 


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