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UMI-77 518303-20-3

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Synonyms ：
Appearance ：
Chemical Formula ：
C18H14BrNO5S2
Solubility ：
Molecular Weight ：
468.34
Storage and Stability ：
in stock
CAS No. ：
518303-20-3
Purity ：
98%+
Introduction
UMI-77 effectively disrupts the interactions between BL-Noxa and cellular Mcl-1, as well as Mcl-1/Bax protein–protein interactions. UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induced apoptosis in pancreatic cancer through activation of the intrinsic apoptotic pathway and/or Bax conformational change. 

In a BxPC-3 xenograft mouse model, UMI-77 (60 mg/kg i.v.) exhibits single-agent antitumor activity without any damage normal tissues. 

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