TTNPB 71441-28-6

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Synonyms

：

Appearance

：

Chemical Formula

：

C24H28O2

Solubility

：

Molecular Weight

：

348.48

Storage and Stability

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in stock

CAS No.

：

71441-28-6

Purity

：

98%+

Introduction

TTNPB binds to nuclear retinoic acid receptors with high affinity, inhibits binding of [3H]tRA with IC50 of 3.8 nM, 4.0 nM, and 4.5 nM for mRARα, β, and γ, respectively. TTNPB increases transcriptional activation of Mouse RARs in JEG-3 cells after 72 h using conditioned media with EC50 of 2.0 nM, 1.1 nM and 0.8 nM for mRARα, β, and γ, respectively. TTNPB inhibits the growth of normal human mammary epithelial cells (HMECs) and estrogen receptor-positive (ER-positive) breast cancer cells by inducing G1 cell cycle blockade. TTNPB causes a concentration-dependent decrease in ES-D3 cell differentiation.

TTNPB (0.25 mg/kg) causes growth inhibition in both MXT-HS and MXT-HI models by inducing cell apoptosis

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TTNPB 71441-28-6

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TTNPB 71441-28-6

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CAS No. ：

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