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TMP269 1314890-29-3

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Synonyms ：
Appearance ：
Chemical Formula ：
C25H21F3N4O3S
Solubility ：
Molecular Weight ：
514.52
Storage and Stability ：
in stock
CAS No. ：
1314890-29-3
Purity ：
98%+
Introduction
TMP269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.

TMP269 has no impact on the mitochondrial activity and/or the viability of human CD4+ T cells at 10 μM, and may be used as tools to identify the endogenous substrates of the class IIa HDAC enzymes. In IEC-18 intestinal epithelial cells, TMP269 prevents cell cycle progression, DNA synthesis, and proliferation induced in response to G protein-coupled receptor/PKD1 activation.


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