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C20H23N3O2S |
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369.48 |
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in stock |
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380315-80-0 |
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98%+ |
Introduction
Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family.
Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts
Products for scientific research use only