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Tenovin-1 380315-80-0

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Synonyms
Appearance
Chemical Formula
C20H23N3O2S
Solubility
Molecular Weight
369.48
Storage and Stability
in stock
CAS No.
380315-80-0
Purity
98%+
Introduction
Tenovin-1 is a p53 activator and elevates the amount of p53 protein within 2 hr of treatment. Tenovin-1 treatment does not alter p53 mRNA levels. Tenovin-1 (10μM) protects p53 from mdm2-mediated degradation with little effect on p53 synthesis. Tenovin-1 represses cell growth, and induces apoptosis in a panel of tumor cells expressing p53. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family. 

Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts

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