SU 9516 377090-84-1

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Synonyms

：

Appearance

：

Chemical Formula

：

C13H11N3O2

Solubility

：

Molecular Weight

：

241.25

Storage and Stability

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in stock

CAS No.

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377090-84-1

Purity

：

98%+

Introduction

SU9516 decreases cdk2-specific phosphorylation of the retinoblastoma protein pRB, increases caspase-3 activation, and alters cell cycle in RKO and SW480 cells. SU9516 also inhibits the cell proliferation, and induces cell apoptosis in both cell lines. SU9516 kills leukemic cells through inhibition of RNA Pol II CTD phosphorylation, oxidative damage and transcriptional down-regulation of Mcl-1. In human T-cell leukemia Jurkat cells, SU9516 significantly enhances sensitivity to methotrexate. In addition, SU9516 also suppresses Aurora-A centrosomal localization and consequent centrosome amplification.

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SU 9516 377090-84-1

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SU 9516 377090-84-1

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