SB203580

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Synonyms

：

SB-203580;

Appearance

：

Chemical Formula

：

C21H16FN3OS

Solubility

：

DMSO 43 mg/mL (113.92 mM)

Molecular Weight

：

377.43

Storage and Stability

：

in stock

CAS No.

：

152121-47-6

Purity

：

99%

Introduction

SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells.

SB203580

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SB203580

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