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SL327 305350-87-2

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Synonyms ：
Appearance ：
Chemical Formula ：
C16H12F3N3S
Solubility ：
Molecular Weight ：
335.35
Storage and Stability ：
in stock
CAS No. ：
305350-87-2
Purity ：
98%+
Introduction
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier.

SL327 is a water soluble, structural homologue of the specific MKK1/2 inhibitor U0126 with IC50 of 0.18 μM and 0.22 μM for MEK1 and MEK2 respectively. SL327 has no effect on a variety of other kinases, including PKA, PKC, or CamKII. 

SL327 (50 mg/kg) crosses the blood-brain barrierand and blocks fear conditioning by inhibiting MAPK/ERK phosphorylation.  SL327 (30 mg/kg) significantly impairs spatial learning in mice. SL327 (50 mg/kg) blocks cocaine-induced properties. 

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