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SGI-1027 1020149-73-8

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Synonyms ：
Appearance ：
Chemical Formula ：
C27H23N7O
Solubility ：
Molecular Weight ：
461.52
Storage and Stability ：
in stock
CAS No. ：
1020149-73-8
Purity ：
98%+
Introduction
SGI-1027 inhibits DNA methylation by directly inhibiting DNMTs, and results in selective degradation of DNMT1 in a wide variety of human cancer cell lines. SGI-1027 exhibits minimal or no cytotoxic effect in rat hepatoma H4IIE cells. SGI-1027 (0-100 μM) exhibits a moderate pro-apoptotic effect on U937 human leukemia cell line with no relevant changes on the cell cycle. 

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