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792173-99-0

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Synonyms ：
Appearance ：
Chemical Formula ：
C17H13N5O2
Solubility ：
Molecular Weight ：
319.32
Storage and Stability ：
in stock
CAS No. ：
792173-99-0
Purity ：
98%+
Introduction
In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response.

In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. SB-334867 also inhibits the development of morphine analgesic tolerance in rats. 

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