Sal003 1164470-53-4

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Synonyms

：

Appearance

：

Chemical Formula

：

C18H15Cl4N3OS

Solubility

：

Molecular Weight

：

463.21

Storage and Stability

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in stock

CAS No.

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1164470-53-4

Purity

：

98%+

Introduction

Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.

Sal003 increases eIF2α phosphorylation status by blocking eIF2a phosphatases in cells. In mouse embryonic fibroblasts (MEFs), Sal003 causes dissociation of polysomes by increasing eIF2a phosphorylation. Sal003 impairs late-long-term potentiation (L-LTP) in an ATF4-dependent mode in hippocampal slices from WT mice. In addition, eIF2α phosphorylation by Sal003 also enhances apoptotic signaling induced by subtilase cytotoxin (SubAB).

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Sal003 1164470-53-4

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Sal003 1164470-53-4

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CAS No. ：

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