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RO3280 1062243-51-9

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Synonyms ：
Appearance ：
Chemical Formula ：
C27H35F2N7O3
Solubility ：
Molecular Weight ：
543.61
Storage and Stability ：
in stock
CAS No. ：
1062243-51-9
Purity ：
98%+
Introduction
RO3280 shows the strong anti-proliferative activity against lung cancer cell line H82, colorectal cancer cell HT-29, breast cancer cell MDA-MB-468, prostate cancer cell PC3 and skin cancer cell A375 with IC50s of 5, 10, 19, 12 and 70 nM, respectively. 

RO3280 displays robust antitumor activity in nude mouse implanted with HT-29 human colorectal tumors ranging from 72% tumor growth inhibition when dosed once weekly at 40 mg/kg, to complete tumor regression when dosed more frequently

Products for scientific research use only
 

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