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NMS-873 1418013-75-8

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Synonyms ：
Appearance ：
Chemical Formula ：
C27H28N4O3S2
Solubility ：
Molecular Weight ：
520.67
Storage and Stability ：
in stock
CAS No. ：
1418013-75-8
Purity ：
98%+
Introduction
NMS-873 is an allosteric and specific p97 inhibitor with IC50 of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).

NMS-873 reduces p97 sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873, as a p97 inhibitor, produces antiproliferative activity in a variety of hematological and solid tumor lines. The mechanism study indicates that NMS-873 activates the unfolded protein response, interfers with autophagy and thus induces cancer cell death

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