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ML323 1572414-83-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C23H24N6
Solubility ：
Molecular Weight ：
384.48
Storage and Stability ：
in stock
CAS No. ：
1572414-83-5
Purity ：
98%+
Introduction
ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1 with IC50 of 76 nM.

ML323 inhibits the deubiquitination of PCNA and FANCD2 by inhibiting USP1–UAF1 activity in H596 cells. Moreover, ML323 potentiates cisplatin cytotoxicity in NSCLC H596 cells and U2OS osteosarcoma cells by targeting two major DNA damage response pathways (TLS and FA). 

Products for scientific research use only
 

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