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ML141 71203-35-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C22H21N3O3S
Solubility ：
Molecular Weight ：
407.49
Storage and Stability ：
in stock
CAS No. ：
71203-35-5
Purity ：
98%+
Introduction
ML141 (CID-2950007), is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7).

ML141 enhances the ability of TMX to suppress BLBC cell growth through both induction of cell death and suppression of cell division.  ML141 also significantly protects neuroblastoma cells from metformin-induced apoptosis. Moreover, ML141 diminishes K. pneumoniae invasion in a dose-dependent manner. 

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