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471905-41-6

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Synonyms ：
Appearance ：
Chemical Formula ：
C21H21ClF2O4S
Solubility ：
Molecular Weight ：
442.9
Storage and Stability ：
in stock
CAS No. ：
471905-41-6
Purity ：
98%+
Introduction
MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.

MK-0752 is identified as a moderately potent γ-secretase inhibitor, which reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM in human SH-SY5Y cells. In vitro, MK-0752 blocks Notch-intracellular domain (ICD) cleavage and its subsequent nuclear translocation. 

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