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MI-2 1271738-62-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C18H25N5S2
Solubility ：
Molecular Weight ：
375.55
Storage and Stability ：
in stock
CAS No. ：
1271738-62-5
Purity ：
98%+
Introduction
MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.

In HEK293 cells, MI-2 accessed the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-2 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. MI-2 also effectively blocks cell proliferation, and induces cell apoptosis in human MLL leukemia cell lines harboring different MLL translocations. 

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