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Lomeguatrib 192441-08-0

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Synonyms ：
Appearance ：
Chemical Formula ：
C10H8BrN5OS
Solubility ：
Molecular Weight ：
326.17
Storage and Stability ：
in stock
CAS No. ：
192441-08-0
Purity ：
98%+
Introduction
Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.

Lomeguatrib inactivates O6-alkylguanine-DNA-alkyltransferase (ATase) with a IC50 10-fold lower than O6-Benzylguanine. Lomeguatrib inhibits the activity of ATase in Raji cells with IC50 of 10 nM. Lomeguatrib effectively inactivates MGMT in MCF-7 cells with IC50 of ~6nM ). Lomeguatrib (10 μM ) substantially increases the growth inhibitory effects of temozolomide in MCF-7 cells (D60= 10 μM with Lomeguatrib vs 400 μM without). 

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