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LDN-212854 1432597-26-6

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Synonyms ：
Appearance ：
Chemical Formula ：
C25 H22 N6
Solubility ：
Molecular Weight ：
406.48
Storage and Stability ：
in stock
CAS No. ：
1432597-26-6
Purity ：
98%+
Introduction
LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2, about 2-, 66-, 1641-, and 7135-fold selectivity over ALK1, ALK3, ALK4, and ALK5, respectively.

LDN-212854 (6 mg/kg, i.p.) effectively neutralize ALK2 signaling in vivo, and potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva.

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