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KPT-185 1333151-73-7

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Synonyms ：
Appearance ：
Chemical Formula ：
C16H16F3N3O3
Solubility ：
Molecular Weight ：
355.31
Storage and Stability ：
in stock
CAS No. ：
1333151-73-7
Purity ：
98%+
Introduction
KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM.

KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts. KPT-185 reduces CRM1 protein protein level and shows a significant nuclear accumulation of CRM1 cargo proteins.  KPT-185 also inhibits proliferation and promotes apoptosis of pancreatic cancer cells without affecting human pancreatic ductal epithelial cells.

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