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KN-93 Phosphate 1188890-41-6

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Synonyms ：
Appearance ：
Chemical Formula ：
C26 H29 Cl N2 O4 S . H3 O4 P
Solubility ：
Molecular Weight ：
599.03
Storage and Stability ：
in stock
CAS No. ：
1188890-41-6
Purity ：
98%+
Introduction
KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.

KN-93 inhibits dopamine formation in PC12h cells by modulating the reaction rate of TH to reduce the Ca(2+)-mediated phosphorylation levels of the TH molecule. KN-93 inhibits serum-induced fibroblast cell growth with IC50 of 8 μM, and induces apoptosis after prolonged G1 arrest.  KN-93 inhibits androgen receptor activity and p53-independently induces cell death in PCa cells. 

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