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JZL 184 1101854-58-3

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Synonyms ：
Appearance ：
Chemical Formula ：
C27H24N2O9
Solubility ：
Molecular Weight ：
520.49
Storage and Stability ：
in stock
CAS No. ：
1101854-58-3
Purity ：
98%+
Introduction
JZL 184 is the first selective inhibitor of monoacylglycerol lipase (MAGL) with IC50 of 8 nM.

JZL184 is a useful tool for studying the effects of endogenous 2-AG signaling. JZL184 displays time-dependent inhibition of MAGL and exhibits >300-fold selectivity for MAGL over FAAH in vitro. JZL184 does not interact with CB1 or CB2 receptors and does not inhibit the 2-AG biosynthetic enzymes diacylglycerol lipase-αand diacylglycerol lipase-β, or the arachidonic acid–mobilizing enzyme cytosolic phospholipase A2 group IVA.

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