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JNJ-38877605 943540-75-8

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Synonyms ：
Appearance ：
Chemical Formula ：
C19H13F2N7
Solubility ：
Molecular Weight ：
C19H13F2N7
Storage and Stability ：
in stock
CAS No. ：
943540-75-8
Purity ：
98%+
Introduction
JNJ-38877605 is an ATP-competitive inhibitor of c-Met with IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.

JNJ-38877605 shows more than 600-fold selectivity for c-Met compared with more than 200 other diverse tyrosine and serine-threonine kinases and also potently inhibits HGF-stimulated and constitutively activated c-Met phosphorylation in vitro.  In EBC1, GTL16, NCI-H1993, and MKN45 cells, JNJ-38877605 (500 nM) leads to a significant reduction of phosphorylation of Met and RON, another key player in invasive growth.  A recent study shows that JNJ-38877605 is involved in modulating secretion of IL-8, GROa, uPAR and IL-6 in GTL16 cells.

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