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IWR-1-endo 1127442-82-3

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Synonyms ：
Appearance ：
Chemical Formula ：
C25H19N3O3
Solubility ：
Molecular Weight ：
409.44
Storage and Stability ：
in stock
CAS No. ：
1127442-82-3
Purity ：
98%+
Introduction
IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

Although both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. 

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