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IOWH0 321191252-49-9

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Synonyms
Appearance
Chemical Formula
C22H15Br2N3O4
Solubility
Molecular Weight
545.18
Storage and Stability
in stock
CAS No.
1191252-49-9
Purity
98%+
Introduction
IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays.

IOWH032 shows inhibitory activity against CFTR in T84-CFTR cell based assays with IC50 of 6.87 μM. 

In a mouse closed-loop model, IOWH032 causes a statistical significant inhibition against cholera toxin (CTX) induced secretion. IOWH032 (5 mg/kg) reduces the fecal output index by ~70% in a cecetomized rat model.

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