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ID-8 147591-46-6

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Synonyms ：
Appearance ：
Chemical Formula ：
C16H14N2O4
Solubility ：
Molecular Weight ：
298.29
Storage and Stability ：
in stock
CAS No. ：
147591-46-6
Purity ：
98%+
Introduction
ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture.


ID-8 reversibly maintains the long-term culture of ESCs by sustaining Nanog gene expression through Sox2-Oct3/4 activation. [1] ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs. The mechanism study indicates that ID-8 maintains the undifferentiated state in the presence of Wnt by modulating Wnt/β-catenin signaling and enhancing the CBP/β-catenin association in hESCs. [2]


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