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IKK-16 873225-46-8

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Synonyms ：
Appearance ：
Chemical Formula ：
C28H29N5OS
Solubility ：
Molecular Weight ：
483.63
Storage and Stability ：
in stock
CAS No. ：
873225-46-8
Purity ：
98%+
Introduction
IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM in cell-free assays, respectively.


IKK-16 inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. Although IKK-16 shows activity in the IFNγ-induced expression of β2 microglobulin or HLA-DR, its potency in these assays is 4- to 10-fold weaker. [1]


 
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