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HPOB 1429651-50-2

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Synonyms ：
Appearance ：
Chemical Formula ：
C17H18N2O4
Solubility ：
Molecular Weight ：
314.34
Storage and Stability ：
in stock
CAS No. ：
1429651-50-2
Purity ：
98%+
Introduction
HPOB is a potent, selective HDAC6 inhibitor with IC50 of 56 nM, >30-fold selectivity over other HDACs.


In normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces acetylation of α-tubulin, however, not histones, and inhibits cell growth, however, not viability. In HFS cells, HPOB enhances transformed cell death induced by etoposide, doxorubicin, or SAHA. HPOB also enhancing etoposide-induced transformed cell death via the apoptotic pathway in transformed cells. [1]


 
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