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HA14-1 65673-63-4

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Synonyms ：
Appearance ：
Chemical Formula ：
C17H17BrN2O5
Solubility ：
Molecular Weight ：
409.23
Storage and Stability ：
in stock
CAS No. ：
65673-63-4
Purity ：
98%+
Introduction
HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.

HA14-1 is a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of approximately 9 μM. HA14-1 induces the apoptosis of HL-60 cells in a dose-dependent manner via caspase activation. [1] HA14-1 shows cytotoxic effects on HF1A3, HF4.9 and HF28RA follicular lymphoma B cell lines with LC50 of 4.5 μM, 12.6 μM and 8.1 μM respectively. HA14-1 induces apoptosis of HF1A3, HF4.9 and HF28RA cells via caspase and ROS. [2]

 
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