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GNF-5 778277-15-9

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Synonyms ：
Appearance ：
Chemical Formula ：
C20H17F3N4O3
Solubility ：
Molecular Weight ：
418.37
Storage and Stability ：
in stock
CAS No. ：
778277-15-9
Purity ：
98%+
Introduction
GNF-5 is a selective and allosteric Bcr-Abl inhibitor with IC50 of 220 nM.

 
GNF-5, when used in combination with imatinib or nilotinib, suppresses the emergence of resistance mutations in vitro, and displays additive inhibitory activity in biochemical and cellular assays against Bcr-Abl T315I mutant. [1] GNF-5 shows potent antiproliferative activity with EC50 of 430 nM and 580 nM against wt-Bcr-Abl and E255K mutant Bcr-Abl transformed cells, respectively. [2]


 
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