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GNE-0877 1374828-69-9

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Synonyms ：
Appearance ：
Chemical Formula ：
C14H16F3N7
Solubility ：
Molecular Weight ：
339.32
Storage and Stability ：
in stock
CAS No. ：
1374828-69-9
Purity ：
98%+
Introduction
GNE-0877 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 0.7 nM.


GNE-0877 significantly inhibits LRRK2 cellular activity with IC50 of 3 nM, and shows low turnover in human liver microsomes and hepatocytes. Besides, GNE-0877 is also a reversible CYP1A2 inhibitor with IC50 of 0.7 μM. [1]
 
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