FLI-06 313967-18-9

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Synonyms

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Appearance

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Chemical Formula

：

C25H30N2O5

Solubility

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Molecular Weight

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438.52

Storage and Stability

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in stock

CAS No.

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313967-18-9

Purity

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98%+

Introduction

FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.

In HeLa NotchΔE-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER. [1]

Products for scientific research use only

FLI-06 313967-18-9

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FLI-06 313967-18-9

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CAS No. ：

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