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FLI-06 313967-18-9

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Synonyms
Appearance
Chemical Formula
C25H30N2O5
Solubility
Molecular Weight
438.52
Storage and Stability
in stock
CAS No.
313967-18-9
Purity
98%+
Introduction
FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.


In HeLa NotchΔE-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER. [1]

 
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