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FH535 108409-83-2

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Synonyms ：
Appearance ：
Chemical Formula ：
C13H10Cl2N2O4S
Solubility ：
Molecular Weight ：
361.20
Storage and Stability ：
in stock
CAS No. ：
108409-83-2
Purity ：
98%+
Introduction
FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.

FH535 antagonizes β-Catenin/Tcf–mediated transcription, and inhibits recruitment of the coactivators GRIP1 and β-catenin to PPARδ and PPARγ. FH535 shows selective anti-proliferation effect on some cancer cells expressing high or active Wnt/β-catenin pathway. [1] FH535 increases cigarette smoke condensate cytotoxicity, and causes changes in β-catenin and EGR-1 signaling. [2] FH535 has potential therapeutic value in treatment of liver cancer by targeting liver cancer stem cells and hepatocellular carcinoma cell lines. [3]

 
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