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DMH1 1206711-16-1

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Synonyms ：
Appearance ：
Chemical Formula ：
C24 H20 N4 O
Solubility ：
Molecular Weight ：
380.44
Storage and Stability ：
in stock
CAS No. ：
1206711-16-1
Purity ：
98%+
Introduction
DMH1 is a selective BMP receptor inhibitor with IC50 of 107.9 nM for ALK2, exhibiting no inhibition on AMPK, ALK5, KDR (VEGFR-2) or PDGFR.


DMH1 inhibits BMP signaling with IC50 of 100 nM, and selectively inhibits the BMP-induced Smad1/5/8 activation. [1] DMH1 increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. [3] In addition, DMH1 as a BMP inhibitor, significantly reduces NSCLC cell growth, migration and invasion. [4]
 
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