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DAPT 208255-80-5

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Synonyms ：
Appearance ：
Chemical Formula ：
C23H26F2N2O4
Solubility ：
Molecular Weight ：
432.46
Storage and Stability ：
in stock
CAS No. ：
208255-80-5
Purity ：
98%+
Introduction
DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.


In human primary neuronal cultures, DAPT also shows inhibitory effects on Aβ production with IC50 of 115 nM and 200 nM respectively for Aβ total and Aβ42, which is 5-10-fold lower than is observed in HEK 293 cells. [1] A recent study shows that DAPT inhibits the proliferation of SK-MES-1 cells in a concentration-dependent manner with IC50 of 11.3 μM. In addition, DAPT also induces caspase-dependent and caspase-independent apoptosis in lung squamous cell carcinoma cells by inhibiting Notch receptor signaling pathway. [2]


 
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