Dalcetrapib 211513-37-0

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Synonyms

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Appearance

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Chemical Formula

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C23H35NO2S

Solubility

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Molecular Weight

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389.59

Storage and Stability

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in stock

CAS No.

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211513-37-0

Purity

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98%+

Introduction

Dalcetrapib (JTT-705) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol. Phase 3.

Dalcetrapib modulates CETP activity. Dalcetrapib induces a conformational change in CETP, when added to human plasma. CETP-induced pre-β-HDL formation in human plasma is unchanged by Dalcetrapib ≤3 µM and increased at 10 µM. Dalcetrapib statistically and significantly increases pre-β-HDL formation. [1] Dalcetrapib achieves 50% inhibition of CETP activity in human plasma at a concentration of 9 μM. [2] Dalcetrapib inhibits the CETP activity of media in HepG2 in a dose-dependent manner. [3]

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Dalcetrapib 211513-37-0

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